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I use Microsoft Security Essentials but it seems to miss a lot of viruses. I haven't been infected on my home machine but I've seen a lot of cases on other people's computers who have it and are infected.
Evidently M$ has an enterprise version of Security Essentials called Microsoft ForeFront. We're looking into it at work since it can manage updates and other things from a central server.
I hear Kapersky is a pretty decent AV. Think Norton and Symantec cause more problems than they are worth.
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