I have been playing around with one of the MEDs on Windows 10 Professional, particularly dfbhdmedv205c.
I managed to replicate some of the issues mentioned above and I appear to have solved them using ACT (Application Compatibility Toolkit).
ACT was used by Scott and myself to fix the border on DF1 and the low swap file warning message on LW etc.
If anyone would be able to test the fix (link below) and post their findings that would be great, if succesful then I will apply it to the other versions of MEDs.
v205c MED Fix Test